Ph-triggered osmotic bursting delivery devices

Details Ph-triggered osmotic bursting delivery devices Ph-triggered osmotic bursting delivery devices

A - Human Necessities

61

K

A61K 9/22 (2006.01) A61K 9/00 (2006.01) A61K 9/28 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01)

Patent

CA 2116288

An osmotic bursting device for dispensing a beneficial agent to an aqueous environment. The device comprises a beneficial agent and osmagent surrounded at least in part by a semipermeable membrane. Alternatively the beneficial agent may also function as the osmagent. The semipermeable membrane is permeable to water and substantially impermeable to the beneficial agent and osmagent. A trigger means is attached to the semipermeable membrane (e.g., joins two capsulehalves). The trigger means is activated by a pH of from 3 to 9 and triggers the eventual, but sudden, delivery of the beneficial agent. These devices enable thePH-triggered release of the beneficial agent core as a bolus by osmotic bursting.]

Dispositif de rupture osmotique pour distribuer un agent utile dans un milieu aquatique. Le dispositif comprend un agent utile et un agent osmotique entourés au moins en partie par une membrane semiperméable. L'agent utile peut aussi agir comme agent osmotique. La membrane semiperméable est perméable à l'eau et plus ou moins imperméable à l'agent utile et à l'agent osmotique. Un système déclencheur est fixé à la membrane semiperméable (elle joint par exemple les deux moitiés d'une capsule). Le système est activé par un pH de 3 à 9 et déclenche la libération éventuelle, mais soudaine, de l'agent utile. Ces dispositifs permettent la libération déclenchée par le pH d'un agent utile sous forme de bolus par rupture osmotique.

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