Phage defense rotation strategy

Details Phage defense rotation strategy Phage defense rotation strategy

C - Chemistry, Metallurgy

12

N

C12N 1/20 (2006.01) C12N 1/04 (2006.01) C12N 15/00 (2006.01) C12N 15/52 (2006.01) C12N 15/74 (2006.01)

Patent

CA 2050533

A phage defense rotation strategy for use in the successive fermentations of a substrate in a fermentation plant is disclosed. The strategy comprises (a) fermenting substrate with a first bacterial culture comprising a bacterial strain capable of fermenting the substrate and, preferably, carrying a first phage defense mechanism; and then (b) fermenting the substrate with a second bacterial culture comprising a second bacterial strain isogenic with the first bacterial strain, wherein the second strain carries a second phage defense mechanism different from the first phage defense mechanism. Also disclosed is a mixed bacterial culture capable of fermenting a substrate. The mixed culture comprises (a) a first bacterial strain carrying a first phage defense mechanism: and (b) a second bacterial strain isogenic with the first strain, wherein the second strain carries a phage defense mechanism different from the phage defense mechanism carried by the first strain.

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