Phage display libraries of human vh fragments

Details Phage display libraries of human vh fragments Phage display libraries of human vh fragments

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C12N 15/10 (2006.01) C12N 15/63 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2447832

Phage display libraries are taught in which the recombinant phage population displays a plurality of potential binding fragments having preferred characteristics of solubility and/or intermolecular interaction. Also taught are methods of biasing display libraries to produce variants which more closely approximate the preferred characteristics of the parental binding fragment.

L'invention concerne des bibliothèques d'affichage de phages, dans lesquelles la population de phages recombinants présente une pluralité de fragments de liaison potentielle dotés de caractéristiques de solubilité et/ou d'interaction moléculaire. Cette invention concerne aussi des méthodes de polarisation des bibliothèques d'affichage de manière à produire des variants qui sont encore plus proches des caractéristiques préférées du fragment de liaison parentale.

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