Phagemids coexpressing a surface receptor and a surface...

Details Phagemids coexpressing a surface receptor and a surface... Phagemids coexpressing a surface receptor and a surface...

C - Chemistry, Metallurgy

12

N

C12N 15/70 (2006.01) C07K 14/705 (2006.01) C12N 7/01 (2006.01) C12N 15/62 (2006.01) C12N 15/64 (2006.01) C40B 40/02 (2006.01) C40B 40/10 (2006.01) G01N 33/566 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2143104

A filamentous phage is described comprising a matrix that includes a heterologous polypeptide fused to a first filamentous phage coat protein membrane anchor and a heterodimeric receptor comprised of first and second receptor polypeptides, wherein one of the receptor polypeptides is fused to a second filamentous phage coat protein membrane anchor. Filamentous phage expressing anchored heterodimeric receptors and dimers of heterologous polypeptides where a first subunit of the dimer is fused to a coat protein membrane anchor and the second subunit of the dimer is soluble heteromeric receptor are also described..

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