C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A01K 67/033 (2006.01) A61K 31/711 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 7/06 (2006.01) A61P 9/10 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/08 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2318935
The invention relates to a signal transduction pathway which promotes phagocytosis of apoptotic cells and in particular relates to a protein known as CED-6 in the nematode worm C. elegans, human equivalents of said protein and nucleic acids encoding them. The invention also relates to use of the proteins and encoding nucleic acids in assay methods for detecting compounds which enhance or inhibit the aforesaid signal transduction pathway and use of the proteins, nucleic acids and identified enhancer or inhibitor compounds in methods of treatment of human or animal disease.
L'invention concerne une voie de transduction du signal favorisant la phagocytose de cellules apoptotiques et, en particulier, une protéine appelée CED-6 dans le ver nématode C. elegans, des équivalents humains de ladite protéine et des acides nucléiques codant ces éléments. L'invention concerne également l'utilisation desdits protéines et acides nucléiques codants dans des épreuves de dosage servant à détecter des composés qui renforcent ou inhibent ladite voie de transduction du signal et mettent en oeuvre lesdits protéines, acides nucléiques et composés promoteurs ou inhibiteurs identifiés dans des procédés de traitement de maladies humaines ou animales.
Bogaert Thierry Andre Oliver Eddy
Hengartner Michael O.
Liu Qiong
Van Criekinge Wim Maria Rene
Cold Spring Harbor Laboratory
Devgen N.v.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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