A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) A61P 25/00 (2006.01) A61P 25/16 (2006.01) A61P 43/00 (2006.01) C07D 215/20 (2006.01) C07D 215/26 (2006.01) C07D 215/38 (2006.01) C07D 215/40 (2006.01) C07D 215/48 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 215/22 (2006.01)
Patent
CA 2745015
The present invention provides a pharmaceutical agent that inhibits the chronic progression of Parkinson's disease or protects dopamine neurons from disease etiology, thereby suppressing the progression of neurological dysfunction, so as to prolong the period of time until L-dopa is administered while also improving neuronal function; the pharmaceutical agent of the invention comprising as an active ingredient a quinolone compound represented by Formula (1): (see formula 1) or a salt thereof, wherein: R1 represents hydrogen or the like; R2 represents hydrogen or the like; R3 represents substituted or unsubstituted phenyl or the like; R4 represents hydrogen or the like; R5 represents hydrogen or the like; R6 represents hydrogen or the like; and R7 represents hydroxy or the like.
La présente invention concerne un agent pharmaceutique capable d'inhiber la progression chronique du parkinson ou de protéger les neurones dopaminergiques de façon à inhiber la progression d'une dysfonction du système nerveux, et donc à retarder l'administration de L-DOPA, cet agent pharmaceutique apportant une amélioration des fonctions considérées. L'invention concerne ainsi de façon spécifique un agent pharmaceutique comprenant un composé de quinolone représenté par la formule générale (1) ou l'un de ses sels. Dans cette formule, R1 est atome d'hydrogène ou analogue; R2 est atome d'hydrogène ou analogue; R3 est groupe phényle éventuellement substitué, ou analogue; R4 est atome d'hydrogène ou analogue; R5 est atome d'hydrogène ou analogue; R6 est atome d'hydrogène ou analogue; et R7 est groupe hydroxy ou analogue.
Matsuzaki Takayuki
Mori Atsushi
Nakai Masami
Ochi Yuji
Otsubo Kenji
Marks & Clerk
Otsuka Pharmaceutical Co. Ltd.
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