Pharmaceutical agents that contain perfluoroalkyl-containing...

Details Pharmaceutical agents that contain perfluoroalkyl-containing... Pharmaceutical agents that contain perfluoroalkyl-containing...

A - Human Necessities

61

K

A61K 33/24 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/22 (2006.01) A61K 31/28 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) A61K 31/555 (2006.01) A61K 31/704 (2006.01) A61K 45/06 (2006.01) A61K 49/00 (2006.01) A61K 49/06 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2247253

The invention relates to pharmaceutical agents containing perfluoroalkylated metal complexes of the general formula (I) RF-L-A and the use thereof in tumour therapy and interventional radiology, in which formula RF is a perfluorinated, straight-chain or branched carbon chain with the formula - CnF2nX, in which X is a terminal fluorine, chlorine, bromine, iodine or hydrogen atom and n represents the numbers 4-30, L is a binding group, and A is a metal complex or the salts thereof of organic and/or inorganic bases or amino acids or amino acid amides. L and A are defined in detail in the description.

L'invention concerne des agents pharmaceutiques renfermant des complexes métalliques perfluoralkylés de la formule générale (I) RF-L-A et leur utilisation dans le traitement des tumeurs et en radiologie interventionnelle. Dans la formule précitée, RF est une chaîne carbonée perfluorée droite ou ramifiée ayant la formule -CnF2nX dans laquelle X est un atome de fluor, chlore, brome, iode ou hydrogène en fin de chaîne et n représente les nombres 4-30, L est un groupe de liaison, et A représente un complexe métallique ou ses sels de bases organiques et/ou inorganiques ou bien d'aminoacides ou encore d'amides d'aminoacides. L et A sont définis en détail dans la description.

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