Pharmaceutical articles of manufacture comprising selective...

Details Pharmaceutical articles of manufacture comprising selective... Pharmaceutical articles of manufacture comprising selective...

A - Human Necessities

61

K

A61K 31/495 (2006.01) A61J 1/00 (2006.01) A61K 9/14 (2006.01) A61K 31/00 (2006.01) A61K 31/4985 (2006.01)

Patent

CA 2307101

The present invention relates to highly selective phosphodiesterase (PDE) enzyme inhibitors and to their use in pharmaceutical articles of manufacture. In particular, the present invention relates to potent inhibitors of cyclic guanosine 3',5'-monophosphate specific phosphodiesterase type 5 (PDE5) that when incorporated into a pharmaceutical product at about 1 to about 20 mg unit dosage are useful for the treatment of sexual dysfunction. The articles of manufacture described herein are characterized by selective PDES inhibition, and accordingly, provide a benefit in therapeutic areas where inhibition of PDE5 is desired, with minimization or elimination of adverse side effects resulting from inhibition of other phosphodiesterase enzymes.

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