Pharmaceutical capsules from improved thermogelling methyl...

Details Pharmaceutical capsules from improved thermogelling methyl... Pharmaceutical capsules from improved thermogelling methyl...

A - Human Necessities

61

J

167/154, 167/169

A61J 3/07 (2006.01) A61K 9/48 (2006.01)

Patent

CA 1072445

A B S T R A C T Improved thermogelling methyl cellulose ether compositions for preparing pharmaceutical capsules by the pin dip coating process are prepared by blending water- -soluble methyl and C2-C3 hydroxyalkyl cellulose ethers to obtain an essentially Newtonian dip coating solution and a high wet thermal gel yield strength. These properties require a cellulose ether with a relatively narrow mole- cular weight distribution. Blends of low viscosity methyl cellulose and hydroxypropylmethyl cellulose ethers provide particularly suitable dip solution properties, wet gel yield strength and capsule dissolution rates.

240835

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