Pharmaceutical combination

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/519 (2006.01) A61K 45/00 (2006.01) A61P 1/00 (2006.01) A61P 13/12 (2006.01) A61P 19/00 (2006.01) A61P 25/00 (2006.01) A61P 43/00 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2645018

Disclosed is a pharmaceutical combination comprising a calcium receptor modulator and a bone resorption inhibitor, wherein the calcium receptor modulator comprises a compound represented by the formula (I) or a salt thereof or a prodrug of the compound or the salt. (I) wherein the ring A represents a 5- to 7-membered ring which may be substituted; the ring B represents a 5- to 7-membered heterocyclic ring which may be substituted; X1 represents CR1 (wherein R1 represents a hydrogen, a hydrocarbon group which may be substituted, or the like) or the like; X2 represents N or the like; Y represents C or the like; Ar represents a cyclic group which may be substituted; R represents a hydrocarbon group which may be substituted or the like; and (a) represents a single or double bond.

La présente invention concerne une combinaison pharmaceutique comprenant un modulateur de récepteur de calcium et un inhibiteur de résorption des os, ledit modulateur de récepteur de calcium comprenant un composé de formule (I) ou un sel dudit composé ou un promédicament du composé ou du sel. (I) Le cycle A représente un cycle comportant 5 à 7 chaînons éventuellement substitué; le cycle B représente un cycle comportant 5 à 7 chaînons éventuellement substitué; X1 représente CR1 (où R1 représente un atome d'hydrogène, un groupement hydrocarbure éventuellement substitué, etc.), etc.; X2 représente N, etc.; Y représente C, etc.; Ar représente un groupement cyclique éventuellement substitué; R représente un groupement hydrocarbure éventuellement substitué, etc.; et (***) représente une liaison simple ou double.

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