A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/277 (2006.01) A61K 31/165 (2006.01) A61P 5/28 (2006.01) A61P 5/32 (2006.01)
Patent
CA 2407028
The present invention relates to a pharmaceutical product, daily dose or dose regimen comprising 4'-cyano-.alpha.',.alpha.',.alpha.'-trifluoro-3-(4- fluorophenylsulphonyl)-2-hydroxy-2-methylpropriono-m-toluidide (compound I) and tamoxifen. The product comprises compound I and tamoxifen in a ratio of 25 to 350:0.5 to 100 respectively. The invention also relates to a method of providing an anti-antrogenic effect and an anti-oestrogenic effect in a patient, wherein the anti-oestrogenic effects is provided substantially without causing an additional increase in the levels of circulating androgens.
L'invention concerne un produit pharmaceutique, une dose quotidienne ou un régime posologique contenant 4'-cyano-.alpha.',.alpha.',.alpha.'-trifluoro-3-(4-fluorophénylsulphonyl)-2-hydroxy-2-méthylpropriono-<i>m</i>-toluidide (composé I) et du tamoxifène. Le produit contient le composé I et le tamoxifène selon un rapport de 25 à 350 : 0,5 à 100 respectivement. L'invention concerne également un procédé permettant de produire un effet anti-androgénique et anti-oestrogénique chez un patient, l'effet anti-oestrogénique étant produit quasiment sans entraîner d'augmentation supplémentaire des niveaux d'androgènes circulants.
Furr Barrington
Astrazeneca Ab
Fetherstonhaugh & Co.
LandOfFree
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