Pharmaceutical combination preparation of an inhibitor of...

A - Human Necessities – 61 – K

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A61K 31/155 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2245776

Pharmaceutical combination preparation of an inhibitor of the sodium/hydrogen exchanger and a medicament for the treatment of cardiovascular diseases These combinations of an NHE inhibitor can comprise one or more therapeutically active compounds having cardiovascular activity. The combination of the cardioprotective properties with known therapies of cardiovascular diseases leads on the one hand to an improvement of the quality of the treatment and on the other hand in a large number of combinations to an additive or potentiated increase of the cardiovascular effects of the individual active compounds alone.

La présente invention fait état d'une préparation pharmaceutique combinée constituée d'un inhibiteur d'échangeur de sodium/d'hydrogène (NHE) et d'un médicament pour le traitement de maladies cardiovasculaires. Ces préparations combinées contenant un inhibiteur du NHE peuvent comprendre un ou plusieurs composés actifs ayant un effet cardiovasculaire. En combinant leurs caractéristiques cardioprotectrices aux thérapies connues utilisées pour traiter les maladies cardiovasculaires on obtient d'une part un traitement de qualité accrue et d'une autre part, dans un grand nombre de combinaisons, une augmentation additive ou synergique des effets cardiovasculaires des composés actifs individuels utilisés seuls.

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