Pharmaceutical combinations and their use in treating...

A - Human Necessities – 61 – K

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Details

A61K 31/00 (2006.01) A61K 31/135 (2006.01) A61K 31/138 (2006.01) A61K 31/195 (2006.01) A61K 31/4045 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2388959

The present invention relates to a combination of a first agent including either a 5-HT4 receptor agonist or antagonist or a 5-HT3 receptor antagonist and a co-agent and pharmaceutical compositions and formulations containing the combination. The pharmaceutical combination may be employed for the treatment of altered gastrointestinal motility, sensitivity, secretion or abdominal disorders. The dosage is preferably oral. The preferred first agent is tegaserod.

La présente invention concerne une combinaison d'un premier agent comprenant soit un agoniste ou un antagoniste du récepteur 5-HT¿4? soit un antagoniste du récepteur 5-HT¿3? et un co-agent, ainsi que des compositions et des formulations pharmaceutiques renfermant cette combinaison. Cette combinaison peut être utilisée pour le traitement de motilité, de sensibilité et de sécrétion gastro-intestinales altérées ou de douleurs abdominales. L'administration se fait, de préférence, par voie orale. Le premier agent préféré est le tégastérode.

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