Pharmaceutical combinations comprising rdea119/bay 869766...

A - Human Necessities – 61 – K

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A61K 31/18 (2006.01) A61K 31/185 (2006.01) A61K 31/4188 (2006.01) A61K 31/436 (2006.01) A61K 31/517 (2006.01) A61K 31/7064 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2754913

The present invention relates to the field of oncology and provides compositions and methods for treating specific cancers, including non small cell lung cancer, breast cancer, thyroid cancer, pancreatic cancer, colon cancer, melanoma, hepatoma and adenocarcinoma. Particularly, compositions and methods involving administration, either simultaneously or sequentially, of pharmaceutical combinations comprising (S)-N- (3,4-difluoro-2-(2-fluoro-4- iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl) cyclopropane-1-sulfonamide with other compounds, to patients suffering from cancer are described.

La présente invention concerne le domaine de l'oncologie et propose des compositions et des procédés pour traiter des cancers spécifiques, comprenant un cancer du poumon non à petites cellules, un cancer du sein, un cancer de la thyroïde, un cancer du pancréas, un cancer du côlon, un mélanome, un hépatome et un adénocarcinome. En particulier, l'invention porte sur des compositions et des procédés mettant en jeu l'administration soit simultanément soit séquentiellement de combinaisons pharmaceutiques comprenant du (S)N-(3,4-difluoro-2-(2-fluoro-4-iodophénylamino)-6-méthoxyphényl)-l-(2,3-dihydroxypropyl)cyclopropane-lsulfonamide avec d'autres composés, à des patients souffrant de cancer.

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