Pharmaceutical combinations containing an inhibitor of...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/60 (2006.01) A61K 31/216 (2006.01) A61K 31/4365 (2006.01) A61P 7/02 (2006.01)

Patent

CA 2574920

The present invention relates to a novel pharmaceutical combination, containing an inhibitor of platelet aggregation and a fÊbrate, where the inhibitor of platelet aggregation is preferably either aspirin or clopidogreL Such a pharmaceutical combination of an inhibitor of platelet aggregation and a fÊbrate is expected to be useful in the treatment and/or prevention of myocardial infarction (heart attack), cardiac arrest, peripheral vascular disease (including symptomatic carotid artery disease), congestive heart failure, ischemic heart disease, angina pectoris (including unstable angina), sudden cardiac death, unstable angina, as well as cerebrovascular events such as cerebral infarction, cerebral thrombosis, cerebral ischemia and transient ischemic attack, disorders related to bypass operations (angioplasty), fitting of endovascular prostheses and restenosis, and inflammatory disorders, including arthritic conditions such as rheumatoid arthritis and osteoarthritis, as well as asthma or related airway or respiratory inflammatory disorders.

La présente invention concerne un nouveau mélange pharmaceutique contenant un inhibiteur d'agrégation plaquettaire et un hydrate, l'inhibiteur d'agrégation plaquettaire étant, de préférence, de l'aspirine ou du clopidogrel. Un tel mélange pharmaceutique d'un inhibiteur d'agrégation plaquettaire et d'un fibrate est supposé être utilisé dans le traitement et/ou la prévention d'un infarctus du myocarde (crise cardiaque), d'un arrêt cardiaque, d'une maladie vasculaire périphérique (notamment, une maladie de l'artère carotide symptomatique), d'une insuffisance cardiaque congestive, d'une cardiopathie ischémique, d'une angine de poitrine (y compris, une angine instable), d'une cardioplégie soudaine, d'une angine instable, ainsi que d'accidents cérébrovasculaires, tels qu'un infarctus cérébral, une thrombose cérébrale, une ischémie cérébrale, et une attaque ischémique transitoire, de troubles liés à des interventions chirurgicales de pontage (angioplastie), d'une installation d'endoprothèse vasculaire, et d'une resténose, et de troubles inflammatoires, notamment, des troubles arthritiques, tels que la polyarthrite rhumatoïde et l'arthrose, ainsi que l'asthme et des troubles inflammatoires respiratoires associés ou des voies aériennes.

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