A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/49 (2006.01) A61K 9/20 (2006.01) A61K 31/445 (2006.01) A61K 31/4453 (2006.01) A61K 31/453 (2006.01) A61K 38/16 (2006.01) A61K 38/46 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2356545
This invention relates to methods of treating traumatic brain injury (TBI) or hypoxic or ischemic stroke, comprising administering to a patient in need of such treatment an NR2B subtype selective N-methyl-D-aspartate (NMDA) receptor antagonist in combination with either: (a) a sodium channel antagonist; (b) a nitric oxide synthase (NOS) inhibitor; (c) a glycine site antagonist; (d) a potassium channel opener; (e) an AMPA/ kainate receptor antagonist; (f) a calcium channel antagonist; (g) a GABA-A receptor modulator (e.g., a GABA- A receptor agonist); or (h) an antiinflammatory agent. This invention also relates to methods of treating hypoxic or ischemic stroke comprising administering to a patient in need of such treatment an NMDA receptor antagonist in combination with a thrombolytic agent.
Chenard Bertrand Leo
Menniti Frank Samuel
Saltarelli Mario David
Pfizer Products Inc.
Smart & Biggar
LandOfFree
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