Pharmaceutical combinations of cox-2 inhibitors and opiates

Details Pharmaceutical combinations of cox-2 inhibitors and opiates Pharmaceutical combinations of cox-2 inhibitors and opiates

A - Human Necessities

61

K

A61K 31/5415 (2006.01) A61K 31/167 (2006.01) A61K 31/485 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2476939

ABSTRACTA pharmaceutical composition comprises a combination of a selective or specific COX 2 inhibitor or a pharmaceutically acceptable salt or derivative thereof and an opiate or a pharmaceutically acceptable salt or derivative thereof, for example a combination of meloxicam and codeine, as active ingredients, and a pharmaceutically acceptable carrier. It may include a centrally-acting cyclo-oxygenase inhibitor such as paracetamol or its pharmaceutically acceptable salts or derivatives. The pharmaceutical compositions are used in methods of providing symptomatic relief or treatment of pain, in an algesic and/or hyperalgesic state, with or without fever, in particular that associated with inflammation such as that associated with trauma, osteoarthritis, rheumatoid arthritis, non-inflammatory myalgia or dysmenorrhoea.

L'invention concerne une composition pharmaceutique renfermant une combinaison d'un inhibiteur s~lectif ou sp~cifique de COX 2 ou d'un sel ou d'un d~riv~ acceptable sur le plan pharmaceutique de celui-ci et un opiac~ ou un sel ou un d~riv~ acceptable sur le plan pharmaceutique de celui-ci, par exemple, une combinaison de m~loxicame et de cod~ine, comme principes actifs, ainsi qu'un excipient acceptable sur le plan pharmaceutique. La composition peut comprendre un inhibiteur de cyclo-oxyg~nase ~ action centrale, tel que du parac~tamol ou ses sels ou d~riv~s acceptables sur le plan pharmaceutique. Les compositions pharmaceutiques sont utilis~es dans des m~thodes permettant de soulager des symptÙmes ou de traiter des douleurs, dans un ~tat alg~sique et/ou hyperalg~sique, avec ou sans fi­vre, sp~cialement associ~s ~ une inflammation, telle que celle li~e ~ un traumatisme, une osth~oarthrose, une polyarthrite rhumato~de, une myalgie non inflammatoire ou une dysm~norrh~e.

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