Pharmaceutical composition

A - Human Necessities – 61 – K

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167/158, 167/227

A61K 31/47 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01)

Patent

CA 1338438

A pharmaceutical composition comprising 9-ethyl-6,9- dihydro-4,6-dioxo-10-propyl-4H-pyrano[3,2-g]quinoline -2,8-dicarboxylic acid or a pharmaceutically acceptable salt thereof, a pressurised or liquefied gas propellant, and a flavouring agent and/or a sweetening agent is useful in the treatment of reversible obstructive airways disease. The composition preferably contains nedocromil sodium as active ingredient. Flavouring agents which may be used include menthol and peppermint oil. Sweetening agents which may be used include sugar, aspartame, cyclamates and saccharin or salts thereof. The composition preferably includes both a flavouring agent and a sweetening agent. Any conventional aerosol propellant may be used, eg a mixture of Propellant 12 and Propellant 114, and the composition is preferably packaged in a conventional pressurised aerosol canister fitted with a dispensing metering valve.

609453

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