Pharmaceutical composition

A - Human Necessities – 61 – K

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A61K 31/56 (2006.01) A61K 47/32 (2006.01)

Patent

CA 2470200

A pharmaceutical composition comprising: (A) androgen; (B) a cyclic enhancer of the type used in the compositions and methods claimed by U.S. Patent No. 5,023,252 to Hsieh; and (C) a thickening agent; including, for example, a composition in which the cyclic enhancer is a macrocyclic ester or a macrocyclic ketone; the use of the composition to treat a condition, for example, male hypogonadism, in a patient by applying the composition to the membrane of the patient; and a method for making the composition.

L'invention concerne une composition pharmaceutique comprenant: (A) un androgène, (B) un amplificateur cyclique du type utilisé dans les compositions et procédés revendiqués par le brevet U.S. 5,023,252 de Hsieh, et (C) un agent épaississant, notamment, par exemple, une composition dans laquelle l'amplificateur cyclique est un ester macrocyclique ou un cétone macrocyclique. L'invention concerne également l'utilisation de cette composition pour soigner un état pathologique, par exemple l'hypogonadisme masculin, chez un patient, par application de cette composition sur la membrane du patient, ainsi qu'un procédé de fabrication de cette composition.

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