Pharmaceutical composition

A - Human Necessities – 61 – K

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A61K 9/24 (2006.01) A61K 31/485 (2006.01) A61P 19/02 (2006.01)

Patent

CA 2709992

Provided herein are formulations and methods for treating pain in human beings. Also provide are optimal ratios at which an opioid and an opioid antagonist may be combined for administration to humans such that the opioid activity is inhibited. These ratios may also be used to formulate compositions containing both an opioid and an opioid antagonist within a single phar-maceutical dosing unit.

L'invention porte sur des formulations et des procédés pour traiter la douleur chez les être humains. L'invention porte également sur des rapports optimaux auxquels un opioïde et un antagoniste d'opioïde peuvent être combinés pour une administration à des êtres humains de telle sorte que l'activité opioïde est inhibée. Ces rapports peuvent également être utilisés pour formuler des compositions contenant à la fois un opioïde et un antagoniste d'opioïde à l'intérieur d'une seule unité de dosage pharmaceutique.

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