A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/713 (2006.01) A61P 35/04 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2558667
The present invention is related to pharmaceutical compositions for the inhibition of metastases and treatment of cancer such as bladder carcinoma, colon cancer, endometrial cancer, hepatocellular carcinoma, leukemia, lymphoma, melanoma, non-small cell lung cancer (NSCLC), ovarian cancer, pancreatic cancer, prostate cancer, soft tissue cancer, renal cancer, osteosarcoma, mesothelioma, myeloma multiple, bladder carcinoma and esophagcal cancer as well as the use of these pharmaceutical compositions for the treatment of said metastases and cancers. Another aspect of this invention are new antisense oligonucleotides inhibiting the formation of human interleukin 10 and their synthesis. A further aspect of this invention is the use IL-10 antisense oligonucleotides for the preparation of pharmaceutical compositions and for the treatment of cancer and metastases.
La présente invention a trait à des compositions pharmaceutiques pour l'inhibition de métastases et le traitement du cancer tel que le cancer de la vessie, le carcinome, le cancer du côlon, le cancer de l'endomètre, le carcinome hépatocellulaire, la leucémie, le lymphome, le mélanome, le cancer bronchopulmonaire, le cancer de l'ovaire, le cancer pancréatique, le cancer prostatique, le cancer du tissu mou, le cancer rénal, l'ostéosarcome, le mésothéliome, le myélome multiple, le carcinome de la vessie et le cancer de l'oesophage ainsi qu'à l'utilisation de ces compositions pharmaceutiques pour le traitement desdits métastases et cancers. Un autre aspect de la présente invention a trait à de nouveaux oligonucléotides antisens d'inhibition de la formation de l'interleukine 10 humaine et leur synthèse. Encore un autre aspect de la présente invention a trait à l'utilisation des oligonucléotides antisens IL-10 pour la préparation de compositions pharmaceutiques et pour le traitement du cancer et de métastases.
Bischof Astrid
Egger Tamara
Hafner Michael
Jachimczak Piotr
Schlingensiepen Karl-Hermann
Antisense Pharma Gmbh
Kirby Eades Gale Baker
LandOfFree
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