A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01) A61K 39/00 (2006.01) A61K 39/07 (2006.01)
Patent
CA 2599329
A microparticle composition comprising a biodegradable polymer, an immunogenic single-stranded ribonucleic acid (ss-RNA) material, a biologically active macromolecule and a stabilising agent wherein the outer surface of the resulting microparticle is free from adsorbed molecules is described. The composition is effective in providing an immune response in dendritic cells, in particular by stimulating increased production of IFN-.alpha.. Methods of production and uses, in medicine, of pharmaceutical compositions derived from the microparticles are also claimed and described.
La présente invention décrit une composition de microparticules qui comprend un polymère biodégradable, un matériau d~acide ribonucléique immunogène à simple brin (ss-ARN), une macromolécule biologiquement active et un agent stabilisant, où la surface extérieure des microparticules résultantes est exempte de molécules adsorbées. La composition est efficace pour produire une réponse immunitaire dans des cellules dendritiques, en particulier par la stimulation d'une production accrue d'IFN-.alpha.. L~invention revendique et décrit également des procédés de fabrication et des utilisations, en médecine, des compositions pharmaceutiques qui proviennent des macroparticules.
Elvin Stephen J.
Eyles James Edward
Healey Gareth David
Westwood Angela
Fetherstonhaugh & Co.
The Secretary Of State For Defence
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