Pharmaceutical composition

Details Pharmaceutical composition Pharmaceutical composition

A - Human Necessities

61

K

A61K 31/5375 (2006.01) A61K 9/08 (2006.01) A61K 9/19 (2006.01) A61K 31/724 (2006.01) A61K 47/20 (2006.01) A61K 47/40 (2006.01) A61P 9/10 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2486571

The present invention provides a pharmaceutical composition comprising N-(3-chloro-4-morpholin-4-yl)phenyl--N'- hydroxyimidoformamidine and sulfobutyl ether .beta.-cyclodextrin or a salt thereof, wherein sulfobutyl ether .beta.-cyclodextrin increases the solubility of N-(3-chloro-4--morpholin-4-yl)phenyl-N'-hydroxyimidoformamidine and improves the stability over time and over heat and light exposure.

La présente invention concerne une composition médicinale qui contient une N-(3-chloro-4-morpholin-4-yl)phényl-N'-hydroxyimidoformamidine, et soit un sulfobutyle-éther à l'état de ?-cyclodextrine, soit l'un de ces sels. Le sulfobutyle-éther à l'état de ?-cyclodextrine augmente la solubilité de la N-(3-chloro-4-morpholin-4-yl)phényl-N'-hydroxyimidoformamidine. Cette composition médicinale se distingue donc par une amélioration de sa stabilité de longue durée et sa stabilité à l'exposition à la chaleur et à la lumière.

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