Pharmaceutical composition

Details Pharmaceutical composition Pharmaceutical composition

A - Human Necessities

61

K

A61K 31/444 (2006.01) A61K 9/32 (2006.01) A61K 9/36 (2006.01) A61K 47/26 (2006.01) A61K 47/32 (2006.01) A61K 47/36 (2006.01) A61K 47/38 (2006.01) A61P 7/02 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2680039

Disclosed is a preparation exhibiting good dissolvability over a wide pH range. Specifically disclosed is a pharmaceutical composition characterized by containing (A) N1-(5-chloropyridin-2-yl)-N2-((1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-{[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c] pyridin-2-yl)carbonyl]amino}cyclohexyl)ethanediamide represented by the formula (1) below, a pharmacologically acceptable salt thereof or a hydrate of any of them, and (B) one or more substances selected from sugar alcohols and water-swelling additives.

L'invention porte sur une préparation présentant une bonne aptitude à la dissolution sur une large plage de pH. De façon spécifique, l'invention porte sur une composition pharmaceutique par le fait qu'elle contient (A) le N1-(5-chloropyridin-2-yl)-N2-((1S,2R,4S)-4-[(diméthylamino)carbonyl]-2-{[(5-méthyl-4,5,6,7-tétrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino}cyclohexyl)éthanediamide représenté par la formule (1) ci-après, un sel pharmacologiquement acceptable de celui-ci ou un hydrate de l'un quelconque de ceux-ci, et (B) une ou plusieurs substances choisies parmi les alcools de sucres et les additifs de gonflement dans l'eau.

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