Pharmaceutical composition and method for neuron rescue in...

A - Human Necessities – 61 – K

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A61K 38/19 (2006.01) A61K 9/16 (2006.01) A61K 9/66 (2006.01) A61K 35/12 (2006.01) A61K 38/18 (2006.01) C12N 11/04 (2006.01) A61K 9/50 (2006.01)

Patent

CA 2213906

The present invention relates to microspheres and pharmaceutical compositions which potentiate neuronal survival. The invention can be used for individuals who have neurological diseases or disorders, or who have a susceptibility to neurological diseases or disorders. In one case, the microspheres are used to treat individuals having ischemia in the brain due to a reduction in blood flow (ischemic-stroke). The invention includes administering a cytokine, such as colony stimulating factor-1 (CSF-1), or other growth factor, in microspheres to the central nervous system (CNS). The microspheres may be implanted in the brain: on top of the pia mater, under the dura, or into the peritoneal cavity. CSF-1 and SCF-mimetics may be used instead of cytokines themselves.

La présente invention concerne des microsphères et des compositions pharmaceutiques qui potentialisent la survie neuronale. L'invention peut être utilisée chez les sujets atteints de maladies ou troubles neurologiques ou qui ont une réceptivité à l'égard des maladies ou troubles neurologiques. Dans un cas, les microsphères sont utilisées pour traiter les sujets atteints d'ischémie cérébrale causée par une réduction de la circulation sanguine (accident cérébro-vasculaire ischémique). L'invention comprend l'administration d'une cytokine, tel le facteur de stimulation des colonies cellulaires-1 (CSF-1), ou un autre facteur de croissance, dans des microsphères dans le système nerveux central (SNC). Les microsphères peuvent être implantées dans le cerveau : sur la pie-mère, sous la dure-mère ou dans la cavité péritonéale. Le CSF-1 et les composés SCF-mimétiques peuvent être utilisés à la place des cytokines elles-mêmes.

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