A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/56 (2006.01) A61K 31/704 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2593161
A pharmaceutical composition and method for regenerating cardiomyocytes in treating or repairing heart muscle damages or injuries caused by an ischemic disease. The pharmaceutical composition contains an active ingredient compound with a backbone structure of Formula (I). The active ingredient compound is capable of (a) increasing viability of myogenic precursor cells to enable said precursor cells to survive through an absolute ischemic period; (b) reconstituting a damaged blood supply network in said heart region where said injured muscle is located; and (c) enhancing cardiomyogenic differentiation efficiency of said precursor cells down cardiac linage, said steps being performed simultaneously or in any particular order.
L'invention concerne une composition pharmaceutique et un procédé de regénération de cardiomyocytes dans le traitement ou la réparation de lésions des muscles cardiaques causées par une maladie ischémique. La composition pharmaceutique contient un principe actif à structure squelette de formule (I). Il est capable de (a) augmenter la viabilité des cellules précurseurs myogéniques afin d'assurer leur survie pendant une période ischémique absolue; (b) reconstituer un réseau d'acheminement de sang endommagé dans une région du coeur où se trouve le muscle affecté; et (c) augmenter l'efficacité de différenciation cardiomyogénique des cellules précurseurs dans la lignée cardiaque, ces étapes s'effectuant simultanément ou selon un quelconque ordre.
Cheng Lei
Li Ming
Liu Hong Wei
Gowling Lafleur Henderson Llp
Lead Billion Limited
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