Pharmaceutical composition based on macrolides for topical...

A - Human Necessities – 61 – K

Patent

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Details

A61K 47/44 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 31/704 (2006.01) A61K 31/7048 (2006.01) A61K 47/14 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2443728

The invention concerns a pharmaceutical composition for preventing and/or treating ocular infections designed for topical application. The invention particularly concerns such a composition which is in the form of a drip-dispensing eye-potion wherein a antibiotic of the class of macrolides, such as azithromycin, is in solution in an oily carrier. Said carrier is in particular of the type of products consisting essentially of medium-chain triglycerides wherein the alcohol functions of the glycerol are completely esterified by saturated hydrocarbon carboxylic acids whereof the molecule comprises 5 to 12 carbon atoms. Preferably the acids are linear-chain fatty acids with comprising 8 to 10 carbon atoms, such as caprylic acid and capric acid. The composition is advantageously prepared by making a solution of the active agent carried out at a temperature not higher than 70 ·C.

L'invention concerne une composition pharmaceutique pour la prévention et/ou le traitement des infections oculaires qui est à utiliser en application locale. Elle vise en particulier une telle composition qui se présente sous la forme d'un collyre distribuable goutte à goutte dans lequel un agent antibiotique de la classe des macrolides, tel que l'azithromycine, est en solution dans un véhicule huileux. Ce véhicule est notamment du type des produits essentiellement constitués de triglycérides à chaîne moyenne dans lesquels les fonctions alcool du glycéril sont entièrement estérifiées par des acides carboxyliques d'hydrocarbures saturés dont la molécule comporte de 5 à 12 atomes de carbone. Il s'agit de préférence d'acides gras à chaîne linéaire comprenant de 8 à 10 atomes de carbone, comme l'acide caprylique et l'acide caprique. La composition est avantageusement préparée par une mise en solution de l'agent actif dans le véhicule huileux effectuée à une température ne dépassant pas 70 ~C.

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