Pharmaceutical composition comprising a bacterial cell...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 11/16 (2006.01) A61K 35/74 (2006.01) A61K 39/02 (2006.01) A61K 39/385 (2006.01) C12N 11/06 (2006.01)

Patent

CA 2591668

The present invention pertains to a composition for the manufacture of a medicament comprising living or dead bacteria with controlled amounts of surface-coupled proteins or proteinaceous compounds and a method for the preparation of the composition. The bacterium provides a multivalent heterologous protein display vehicle that may be used in the manufacture of vaccines or medicaments for delivery via the mucosa.

La présente invention concerne une préparation permettant d'élaborer un médicament. Ladite préparation comprend des bactéries vivantes ou mortes présentant des quantités contrôlées de protéines ou de composés protéiques arrimés à leur surface. La présente invention décrit également une méthode d'élaboration de ladite préparation. Ladite bactérie constitue un vecteur de présentation d'une protéine hétérologue multivalente qui peut être employé dans la fabrication de vaccins ou de médicaments à libération mucosale.

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