A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/155 (2006.01) A61K 31/435 (2006.01) A61K 31/4745 (2006.01) A61P 31/10 (2006.01)
Patent
CA 2465364
The invention is directed to pharmaceutical composition comprising a compound having adenosine A1/A2 agonistic activity, a sodium-hydrogen exchanger inhibitory compound and a pharmaceutically acceptable carrier. The invention is also directed to a method cardioprotection in a patient in need thereof comprising administering to said patient pharmaceutically effective amounts of a compound having adenosine A1/A2 agonistic activity and a sodium-hydrogen exchanger inhibitory compound. This invention is also directed to the use of pharmaceutically effective amounts of a compound having adenosine A1/A2 agonistic activity and a sodium-hydrogen exchanger inhibitory compound in the preparation of a medicament for providing cardioprotection to a patient in need thereof. This invention is also directed to a kit for providing cardioprotection in a patient in need thereof, said kit comprising a plurality of separate containers, wherein at least one of said containers contains a compound having adenosine A1/A2 agonistic activity and at least another of said containers contains a sodium-hydrogen exchanger inhibitory compound, and said containers optionally contain a pharmaceutical carrier.
L'invention concerne une composition pharmaceutique comprenant un composé présentant une activité agoniste de l'adénosine A1/A2, un composé inhibiteur de l'échangeur sodium-hydrogène et un excipient pharmaceutiquement acceptable. L'invention concerne également un procédé de cardioprotection chez un patient qui en a besoin consistant à lui administrer des doses pharmaceutiquement efficaces d'un composé présentant une activité agoniste de l'adénosine A1/A2 et d'un composé inhibiteur de l'échangeur sodium-hydrogène. L'invention concerne en outre l'utilisation de doses pharmaceutiquement efficaces d'un composé présentant une activité agoniste de l'adénosine A1/A2 et d'un composé inhibiteur de l'échangeur sodium-hydrogène dans la préparation d'un médicament assurant une cardioprotection chez un patient qui en a besoin. Elle concerne aussi une trousse permettant d'assurer une cardioprotection chez un patient qui en a besoin, ladite trousse comprenant plusieurs contenants séparés, chacun renfermant un composé présentant une activité agoniste de l'adénosine A1/A2 et au moins un autre contenant renfermant un composé inhibiteur de l'échangeur sodium-hydrogène, lesdits contenants renfermant éventuellement un excipient pharmaceutique.
Downey James M.
Shukla Umesh
Xu Zhelong
Aventis Pharmaceuticals Inc.
Bereskin & Parr
LandOfFree
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