Pharmaceutical composition comprising an alpha2delta ligand...

A - Human Necessities – 61 – K

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A61K 31/403 (2006.01) A61K 31/197 (2006.01) A61P 25/30 (2006.01)

Patent

CA 2535814

Pharmaceutical compositions are disclosed for the treatment of alcohol or cocaine dependence or addiction, tobacco dependence or addiction, reduction of alcohol withdrawal symptoms or aiding in the cessation or lessening of alcohol use or substance abuse or other behavioral dependencies including gambling. The pharmaceutical compositions are comprised of a therapeutically effective combination of an opioid receptor antagonist and an alpha2delta ligand and a pharmaceutically acceptable carrier. The use of these compounds is also disclosed.

L'invention concerne des compositions pharmaceutiques pour le traitement de la dépendance ou de l'accoutumance à l'alcool ou à la cocaïne, au tabac, la réduction des symptômes du sevrage alcoolique ou bien l'aide à l'arrêt ou à la diminution de la consommation d'alcool ou de l'usage de substances toxiques ou encore d'autres dépendances comportementales, notamment le jeu. Ces compositions pharmaceutiques sont constituées d'une association thérapeutiquement efficace d'un antagoniste du récepteur opioïde, d'un ligand alpha2delta et d'un excipient pharmaceutiquement acceptable. L'utilisation de ces composés est également décrite .

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