Pharmaceutical composition comprising an analgesic peptide

Details Pharmaceutical composition comprising an analgesic peptide Pharmaceutical composition comprising an analgesic peptide

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01) C07K 5/097 (2006.01) C07K 5/117 (2006.01) C07K 7/08 (2006.01) C12N 15/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2418793

A pharmaceutical composition for topical administration comprising an analgesic effective amount of a peptide comprising L-amino acids of the formula (I): pGLU-X-Y-Z M (I) and a pharmaceutically acceptable excipient. X is an amino acid selected from the group consisting of GLY, VAL, GLU, ASP, SER, ALA, ASN, GLN, ILE, LEU, PRO, LYS and ARG, Y is TRP or THR, and Z is any L-amino acid, or Z is null. When Z is any L-amino acid, one but not both of Y and Z is TRP, and when Z is null, Y = TRP. An alkyl group may be attached to an amino acid of the peptide. Also disclosed are the peptide, the preparation of the pharmaceutical composition and a topical method of treating or preventing pain in a mammal.

La présente invention concerne une composition pharmaceutique pour administration locale comprenant une quantité suffisante d'un peptide analgésique comprenant les acides L-aminés représentés par la formule générale "pGLU-X-Y-Z M" (I), et un excipient pharmaceutiquement admis. Dans cette formule, X est un acide aminé appartenant au groupe des GLY, VAL, GLU, ASP, SER, ALA, ASN, GLN, ILE, LEU, PRO, LYS et ARG. Y est TRP ou THR, Z étant n'importe quel acide L-aminé ou nul. Lorsque Z est acide L-aminé, seul Y ou Z peut être TRP. En outre, lorsque Z est nul, Y = TRP. Un groupe alkyle peut être attaché à un acide aminé du peptide. L'invention concerne également le peptide, la préparation de la composition pharmaceutique et un procédé topique de traitement ou de prévention de la douleur chez un mammifère.

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