Pharmaceutical composition comprising at least one...

A - Human Necessities – 61 – K

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A61K 45/08 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2626016

The present invention relates to novel and improved compositions of anticancer drugs, preferably taxanes, such as paclitaxel and docetaxel, their derivatives or their analogues, methods of manufacturing these compositions and methods of fractionating the particles in particular size range and methods of treating cancer patients with these compositions, which provide reduced chemotherapy- induced side-effects especially reduced chemotherapy-induced- alopecia. The composition is such that there is substantially no free drug in the said composition.

La présente invention concerne des compositions nouvelles et améliorées de médicaments anticancéreux, de préférence des taxanes, tels que le paclitaxel et le docétaxel, leurs dérivés ou leurs analogues, des procédés de fabrication de ces compositions et des procédés de fractionnement des particules par plage de taille particulière et des procédés de traitement de patients cancéreux avec ces compositions, qui produisent des effets secondaires induits par une chimiothérapie réduits en particulier une alopécie induite par une chimiothérapie réduite. La composition est telle qu'il n'y a sensiblement pas de médicament libre dans ladite composition.

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