Pharmaceutical composition comprising chito-oligomers

Details Pharmaceutical composition comprising chito-oligomers Pharmaceutical composition comprising chito-oligomers

A - Human Necessities

61

K

A61K 31/702 (2006.01) A61K 31/7008 (2006.01) A61K 31/722 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) C07H 5/06 (2006.01) C07H 13/04 (2006.01) C08B 37/08 (2006.01)

Patent

CA 2507926

Compositions are provided comprising chito-oligomers obtainable from chitin, comprising oligomers of N-acetyl glucosamine (NAG) and glucosamine, wherein at least 50% of the oligomers have a chain length of about 2-50, and the degree of deacetylation of the oligomers is in the range of about 0-70%, preferably about 30-50%. The compositions are highly useful as pharmaceutical compositions for treatment of joint disorders such as rheumatoid arthritis and osteoarthritis. Also provided are methods for treatment of joint disorders and treatment against inflammatory activity.

Cette invention se rapporte à des compositions comprenant des chito-oligomères pouvant être obtenus à partir de chitine, ces compositions contenant des oligomères de <I>N</I>-acétyl-glucosamine (NAG) et de glucosamine, au moins 50 % de ces oligomères ayant une longueur de chaîne d'environ 2 à 50 et le degré de déacétylation de ces oligomères étant compris entre environ 0 et 70 %, de préférence entre environ 30 et 50 %. Ces compositions sont très utiles comme compositions pharmaceutiques dans le traitement des lésions des articulations, telles que la polyarthrite rhumatoïde et l'ostéo-arthrite. Cette invention concerne également des procédés de traitement des lésions des articulations et de traitement de l'action inflammatoire.

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