A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/129, 195/1.2
A61K 31/195 (2006.01) A61K 45/02 (1980.01)
Patent
CA 1156145
16336IA TITLE OF THE INVENTION Pharmaceutical Composition Comprising Modified Polyriboinosinic-Polyribocytidylic Acid, for Induction of Interferon in Primates. ABSTRACT OF THE INVENTION A complex of polyriboinosinic-polyribocytidylic acid (poly I:C) with poly-L-lysine hydrobromide ([lysine.HBr]n) having a defined molecular weight is prepared which is about 5-15 times as resistant to hydrolysis by pancreatic ribonuclease as the parent poly I:C. A pharmaceutical solution, con- taining a relatively high concentration of the complex, prepared as described, induces significant antiviral levels of serum interferon in monkeys under conditions in which poly I:C itself induces little or no interferon. An important feature of this invention is that the product is a soluble material requiring no special solubilizing agent, thereby facilitating the preparation of solutions having the desired concentration. The product will hereinafter be designated as poly I:C/poly-L-lysine.
360530
Field A. Kirk
Lampson George P.
Tytell Alfred A.
Goudreau Gage Dubuc
Merck & Co. Inc.
LandOfFree
Pharmaceutical composition comprising modified... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pharmaceutical composition comprising modified..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical composition comprising modified... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-441198