A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/445 (2006.01) A61K 31/4196 (2006.01) A61K 31/7048 (2006.01) A61K 38/00 (2006.01) A61K 45/00 (2006.01) A61P 31/10 (2006.01)
Patent
CA 2664915
Disclosed is a pharmaceutical composition comprising a phenylamidine derivative represented by the general formula: [wherein R1 and R2 independently represent a C3-4 alkyl group which may be substituted] or a salt thereof and at least one substance selected from an azole-type antifungal agent, a polyene-type antifungal agent, a candin-type antifungal agent and a fluoropyrimidine-type antifungal agent. Also disclosed is a method of using a combination of the phenylamidine derivative or the salt thereof and the substance. The pharmaceutical composition and the method are useful for the treatment of a fungal infectioninduced by a fungal pathogen.
La présente invention concerne une composition pharmaceutique contenant un dérivé de phénylamidine représenté par la formule générale : [R1 et R2 représentant indépendamment un groupe alkyle en a C3 à C4 qui peut être substitué] ou un sel de ce dérivé, et au moins une substance choisie parmi un agent antifongique de type azole, un agent antifongique de type polyène, un agent antifongique de type candine et un agent antifongique de type fluoropyrimidine. L'invention concerne également un procédé permettant d'utiliser le dérivé de phénylamidine, ou son sel, combiné à la substance. La composition pharmaceutique et le procédé se révèlent utiles pour le traitement d'une infection fongique induite par un agent pathogène fongique.
Marks & Clerk
Toyoma Chemical Co. Ltd.
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