Pharmaceutical composition comprising progestogens and/or...

A - Human Necessities – 61 – K

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Details

A61K 31/519 (2006.01) A61K 31/00 (2006.01) A61K 31/135 (2006.01) A61K 31/4415 (2006.01) A61K 31/525 (2006.01) A61K 31/565 (2006.01) A61K 31/57 (2006.01) A61K 31/585 (2006.01) A61K 31/7028 (2006.01) A61P 15/12 (2006.01) A61P 15/18 (2006.01)

Patent

CA 2608639

The invention relates to a pharmaceutical composition which contains gestagens, preferably drospirenone, estrogens, preferably ethinylestradiol, and 5-methyl-(6S)-tetrahydrofolate, can be used as an oral contraceptive, and prevents diseases of the consumer caused by folate deficiency, especially cardiovascular diseases, as well as congenital defects caused by folate deficiency after conceiving the embryo, such as neural tube defects, defects of the ventricular valve, urogenital defects, and cheilognathopalatoschisis, without masking the symptoms of vitamin B12 deficiency while facilitating unrestricted usability of the folate component 5-methyl-(6S)-tetrahydrofolate by the organism and thus the biological activity thereof in order to prevent said congenital defects caused by folate deficiency in case of a homozygous or heterozygous methylenetetrahydrofolate reductase polymorphism. In addition, an extended protective effect is maintained after discontinuing the contraceptive.

La présente invention concerne une composition pharmaceutique contenant des gestagènes, de préférence de la drospirénone, des oestrogènes, de préférence de l'éthinylestradiol et du 5-méthyl-(6S)-tétrahydrofolate, qui peut être utilisée comme contraceptif oral et qui peut ainsi prévenir des maladies induites par un déficit en folate chez des consommatrices, en particulier des maladies cardio-vasculaires et, après la conception de l'embryon, des malformations congénitales induites par un déficit en folate, telles que des anomalies du tube neural, des anomalies des ventricules, des anomalies urogénitales, ainsi que des becs-de-lièvre, sans masquer les symptômes d'un déficit en vitamine B12. En cas d'un polymorphisme homozygote ou hétérozygote de la méthylène tétrahydrofolate réductase, cette composition facilite la capacité d'utilisation illimitée des composants de folate 5-méthyl-(6S)-tétrahydrofolate par l'organisme et ainsi leur activité biologique, afin d'éviter les malformations congénitales induites par un déficit en folate susmentionnées. Après arrêt du contraceptif, une action protectrice persistant plus longtemps est maintenue.

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