A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/519 (2006.01) C07D 475/08 (2006.01)
Patent
CA 2754007
There is disclosed a pharmaceutical composition comprising racemic aminopterin or pharmaceutically acceptable salts thereof. There is further disclosed a method to treat a disorder in a patient comprising administering a therapeutically effec-tive amount of racemic aminopterin or pharmaceutically acceptable salts of racemic aminopterin. More particularly, there is dis-closed a method for treating disorders modulated by at least dihydrofolate reductase activity, such as cancers and inflammatory disorders, wherein the method comprises administering to a patient in need thereof a therapeutically effective amount of racemic aminopterin or a pharmaceutically acceptable salt thereof.
L'invention concerne une composition pharmaceutique qui comporte de l'aminoptérine racémique ou ses sels de qualité pharmaceutique. L'invention concerne en outre une méthode de traitement d'un trouble chez un patient, la méthode comportant l'administration d'une quantité efficace d'un point de vue thérapeutique d'aminoptérine racémique ou de ses sels de qualité pharmaceutique. Plus particulièrement, l'invention concerne une méthode de traitement de troubles modulés par au moins une activité de la dihydrofolate réductase, tels que des cancers et des troubles inflammatoires, la méthode comportant l'administration, à un patient en ayant besoin, d'une quantité efficace d'un point de vue thérapeutique d'aminoptérine racémique ou de ses sels de qualité pharmaceutique.
Kahn Stuart J.
Maeda Dean Y.
Morgan Joel R.
Zebala John A.
Aminopterin Llc
Smart & Biggar
LandOfFree
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