Pharmaceutical composition comprising rimeporide for...

A - Human Necessities – 61 – K

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Details

A61K 31/155 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2725209

The invention relates to a pharmaceutical composition comprising as active ingredient an effective amount of 2-Methyl-4,5-di-(methylsulfonyl)-benzoyl-guanidine, or derivatives thereof, for the prophylaxis and therapy of Type II diabetes mellitus, the Metabolic syndrome, diabetic nephropathy and/or neuropathy. Another object of the invention concerns the use of 2-Methyl-4,5-di-(methylsulfonyl)-benzoyl-guanidine, or derivatives thereof, for the enhancement of insulin sensitivity and the preservation or increase of O-cell compensation.

La présente invention concerne une composition pharmaceutique renfermant comme principe actif une quantité efficace de 2-méthyl-4,5-di- (méthylsulfonyl)- benzoyl-guanidine ou ses dérivés, et indiquée pour la prophylaxie et la thérapie du diabète de type II, le syndrome métabolique, ainsi que pour la néphropathie diabétique et/ou la neuropathie diabétique. Un autre objet de linvention concerne lutilisation de la 2-méthyl-4,5-di-(méthylsulfonyl)- benzoyl-guanidine ou de ses dérivés, pour lamplification de la sensibilité à linsuline et la conservation ou laugmentation de la compensation des cellules ß.

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