Pharmaceutical composition comprising serum amyloid p...

A - Human Necessities – 61 – K

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Details

A61K 38/17 (2006.01) A61K 35/16 (2006.01) A61K 47/04 (2006.01) C07K 14/47 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2247388

Pharmaceutical compositions comprising a protein serum amyloid P component (SAP) capable of binding viruses, especially myxovirus, e.g. influenza viruses and thereby preventing the transmission and infection with such viruses. Preferred is mucosal administration, e.g. SAP incorporated in a nose spray or nose drops. Also provided is a method for measuring the binding of SAP to the hemagglutinin of the prevailing influenza virus subtype and strain.

La présente invention concerne des compositions pharmaceutiques comprenant un constituant amyloïde P de sérum (APS) capable de fixer des virus, en particulier les Myxovirus, par exemple les virus de la grippe, et qui empêchent ainsi la transmission et l'injection par de tels virus. L'administration se fait de préférence par les muqueuses, par exemple de l'APS incorporé à un aérosol nasal ou à des gouttes nasales. L'invention concerne aussi un procédé de mesure de la fixation d'APS sur l'hémagglutinine du sous-type et de la souche dominants de virus de la grippe.

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