Pharmaceutical composition comprising shikonin derivatives...

A - Human Necessities – 61 – K

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 31/122 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2678524

The present invention relates to a composition comprising shikonin compounds, especially, isobutyryl shikonin, .beta.,.beta.-dimethylacryl shikonin, isovaleryl shikonin, and .alpha.-methyl-n-butyryl shikonin as an active ingredient for the prevention and treatment of diabetes mellitus and the use thereof. The composition of the present invention showed stimulating effect on the release of insulin in the beta cell of the pancreas due to inhibitory effect on K ATP ion channel of beta cell in pancreas together with promoting effect on the increase of calcium concentration. Therefore, it can be used as the therapeutics, health functional food or food additive for treating and preventing diabetes mellitus.

La présente invention concerne une composition comprenant comme ingrédient actif des composés de shikonine, et notamment de l'isobutyryl shikonine, de la .beta.,.beta.-diméthylacryl shikonine, de l'isovaléryl shikonine et de l'.alpha.-méthyl-n-butyryl shikonine, pour la prévention et le traitement du diabète sucré, ainsi que l'utilisation de cette composition. Il a été observé que la composition de la présente invention présente un effet stimulant sur la libération de l'insuline dans la cellule bêta du pancréas du fait d'un effet inhibiteur sur le canal ionique KATP de la cellule bêta dans le pancréas, conjointement avec un effet promoteur sur l'augmentation de la concentration en calcium. Par conséquent, elle peut être utilisée comme agent thérapeutique, comme aliment fonctionnel diététique ou comme additif alimentaire pour le traitement et la prévention du diabète sucré.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Pharmaceutical composition comprising shikonin derivatives... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pharmaceutical composition comprising shikonin derivatives..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical composition comprising shikonin derivatives... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-2083071

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.