A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/436 (2006.01) A61K 31/137 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2399971
Synergistic combinations of a squalene epoxidase inhibitor such as terbinafine and a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro,33-desoxyascomycin are provided, which are useful in particular in the treatment of diseases involving fungal or suspected fungal infection, for immunomodulation or immunosuppression in conditions in which fungal or suspected fungal colonisation of e.g. the skin plays a role, such as atopic dermatitis and seborrhoeic dermatitis, and in situations of fungal resistance.
L'invention concerne des complexes médicamenteux d'un inhibiteur squalène époxydase, tel que la terbinafine et un immunomodulateur ou un immunosuppresseur macrolide de lymphocyte T, à savoir 33-épichloro-33-désoxyascomycine, utile dans le traitement de maladies impliquant des infections fongiques ou présumées fongiques, lors de l'immunomodulation ou de l'immunosuppression dans des conditions dans lesquelles la colonisation fongique ou présumée fongique, telle que la dermatite atopique et la dermatite séborrhéique, notamment de la peau, joue un rôle, et dans des situations de résistance aux champignons.
Mayer Friedrich Karl
Ryder Neil Stewart
Fetherstonhaugh & Co.
Novartis Ag
LandOfFree
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