Pharmaceutical composition containing a taxane derivative,...

A - Human Necessities – 61 – K

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A61K 9/08 (2006.01) A61K 9/00 (2006.01) A61K 31/337 (2006.01) C07D 305/14 (2006.01)

Patent

CA 2649335

A pharmaceutical composition containing a taxane derivative, destined for the preparation of an infusion solution for administration to patients, containing a concentrate consisting of a pharmaceutically effective amount of docetaxel, a suitable solvent, which is preferably ethanol, a surfactant, which is polysorbate 80 and a pharmaceutically effective amount of an appropriate buffer; and optionally a co-solvent, consisting of an aqueous solution of a pharmaceutically effective amount of polysorbate 80 and optionally suitable organic solvent and/or a pharmaceutically effective amount of an appropriate buffer. This composition shows an excellent chemical and physical stability. The invention includes also a method of preparation of the pharmaceutical composition and the use thereof.

La présente invention a pour objet une composition pharmaceutique contenant un dérivé de taxane, et destinée à l'élaboration d'une solution pour perfusion pour administration à des patients. Cette composition contient un concentré constitué d'une quantité pharmaceutiquement active de docétaxel, un solvant adapté, de préférence l'éthanol, un tensioactif, qui est le polysorbate 80 et une quantité pharmaceutiquement active d'un tampon approprié; et éventuellement un co-solvant, constitué d'une solution aqueuse d'une quantité pharmaceutiquement active de polysorbate 80 et éventuellement d'un solvant organique adapté et/ou d'une quantité pharmaceutiquement active d'un tampon approprié. Cette composition présente une excellente stabilité physico-chimique. La présente invention inclut également une méthode d'élaboration de la composition pharmaceutique ainsi que ses applications.

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