A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01) A61K 31/353 (2006.01) A61K 31/56 (2006.01) A61K 31/70 (2006.01) A61K 31/7105 (2006.01) A61K 31/711 (2006.01) A61K 39/21 (2006.01) A61K 39/235 (2006.01)
Patent
CA 2748520
Disclosed are an anionic drug-containing pharmaceutical composition comprising: an anionic drug as an active ingredient; a cationic lipid; and an amphiphilic block copolymer, wherein the anionic drug forms a complex with the cationic lipid, and the complex is entrapped in the micelle structure of the amphiphilic block copolymer, and a method for preparing the same. The pharmaceutical composition may increase stability of the anionic drug in blood or in a body fluid, and it may enable intracellular delivery to improve efficacy of anionic drugs.
La composition pharmaceutique ci-décrite contient un médicament anionique comme composant actif, un lipide cationique et un copolymère séquencé amphiphile, le médicament anionique formant un complexe avec le lipide cationique, et le complexe étant enfermé dans une structure de micelle du copolymère séquencé amphiphile. L'invention concerne également un procédé de préparation de ladite composition. Cette dernière améliore l'efficacité de médicaments anioniques en permettant leur délivrance dans des cellules et en augmentant leur stabilité dans le sang et les liquides biologiques.
Choi Sung-Won
Kim Se-Ho
La Muhn-Ho
Seo Min-Hyo
Son Ji-Yeon
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
Samyang Corporation
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