A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/215 (2006.01) A61P 35/02 (2006.01)
Patent
CA 2492278
The present invention relates to a pharmaceutical composition useful for treating chronic myeloid leukemia where Bcr-Abl kinase is constitutively expressed in animals and humans, said composition comprising an effective amount of analogs of chlorogenic acid such as neochlorogenic acid (5-O- caffeoyl quinic acid), cryptochlorogenic acid (4-O-Caffeoyl quinic acid), 3-O- (3'-methylcaffeoyl) quinic acid and 5-O-(Caffeoyl-4'-methyl) quinic acid and/or its salts such as sodium, potassium and ammonium together with pharmaceutically acceptable additives.
L'invention concerne une composition pharmaceutique destinée à traiter la leucémie myéloïde chronique dans laquelle la Bcr-Abl kinase est exprimée de manière constitutive chez l'animal et chez l'homme. Cette composition comprend une quantité efficace d'analogues de l'acide chlorogénique tel que l'acide néochlorogénique (acide 5-O-caffeoyl quinique), l'acide cryptochlorogénique (acide 4-O-caffeoyl quinique), l'acide 3-O-(3'-méthylcaffeoyl) quinique et l'acide 5-O-(caffeoyl-4'-méthyl) quinique et/ou leurs sels tels que sodium, potassium and ammonium, ainsi que des additifs pharmaceutiquement acceptables.
Bandyopadhyay Gautam
Bandyopadhyay Santu
Bhattacharya Samir
Pal Bikash Chandra
Roy Kesheb Chandra
Council Of Scientific And Industrial Research
Smart & Biggar
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