A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/196 (2006.01) A61K 47/40 (2006.01)
Patent
CA 2136492
A method of preparing an injectable pharmaceutical or veterinary composition which comprises either diclofenac or a salt thereof and 2-hydroxypropyl beta-cyclodextrin, or an inclusion complex of diclofenac or a salt thereof and 2-hydroxypropyl beta-cyclodextrin, includes the step of dissolving either the diclofenac or salt thereof and the 2-hydroxypropyl beta-cyclodextrin, or the inclusion complex, in water to form a solution, the water having been acidified to a pH such that the pH of the solution is from 6,0 to 8,5 inclusive, in the absence of a phosphate buffer. The composition so produced has good stability on storage.
Bodley Mark David
Glintenkamp Lueta Ann
Penkler Lawrence John
Van Oudtshoorn Michiel Coenraad Bosch
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Farmarc Nederland Bv
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