Pharmaceutical composition containing histamine...

A - Human Necessities – 61 – K

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167/237, 167/245

A61K 31/78 (2006.01) A61K 31/34 (2006.01) A61K 31/415 (2006.01)

Patent

CA 1256377

ABSTRACT PHARMACEUTICAL COMPOSITIONS Pharmaceutical compositions comprising mixtures of a histamine H2-receptor antagonist such as cimetidine or ranitidine and sodium polyacrylate in a specified range of ratios have been found to exhibit synergistic effects in an in vivo test model for anti-ulcer or mucosal-protecting agents. Pharmaceutical compositions comprising mixtures of a histamine H2-receptor antagonist such as cimetidine or ranitidine and sodium polyacrylate in the range of ratios are described for use in the treatment of gastritis or of gastro-duodenal ulcers. In a modification in the mixtures the sodium polyacrylate may be replaced wholly or in part by potassium or ammonium polyacrylate.

502304

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