Pharmaceutical composition containing morphinan derivative...

A - Human Necessities – 61 – K

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A61K 31/485 (2006.01) A61P 25/30 (2006.01) A61P 25/34 (2006.01) A61P 25/36 (2006.01) C07D 489/08 (2006.01)

Patent

CA 2270955

Remedies for drug addiction which contain as the active ingredient k-opioid receptor agonists typified by the compounds represented by general formula (I). These k-opioid receptor agonists are useful as remedies for drug addiction which are reduced in side effects and act on the reward effect expression mechanism so as to inhibit the expression of mental addiction and physical addiction simultaneously, different from the symptomatic therapy conventionally employed in treating drug addiction.

L'invention concerne des remèdes contre la toxicomanie renfermant, comme ingrédient actif, des agonistes des récepteurs kappa -opioïdes que caractérisent les composés représentés par la formule générale (I). Ces agonistes des récepteurs kappa -opioïdes sont utiles comme remèdes contre la toxicomanie; leurs effets secondaires sont réduits et ils agissent sur le mécanisme d'expression à effet de récompense de manière à inhiber simultanément l'expression de la dépendance psychique et physique, méthode qui diffère de la thérapie symptomatique que l'on emploie généralement pour le traitement de la toxicomanie.

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