Pharmaceutical composition containing pentamidine

Details Pharmaceutical composition containing pentamidine Pharmaceutical composition containing pentamidine

A - Human Necessities

61

K

167/271

A61K 31/155 (2006.01) A61K 9/08 (2006.01) A61K 9/72 (2006.01)

Patent

CA 1326453

Abstract Pharmaceutical Compositions An aqueous solution containing, as active ingredient, pentamidine or a pharmaceutically acceptable salt thereof, and having a pH of less than 4.5 is more stable than conventional solutions of pentamidine. The pH of the solution is preferably less than 4.0, more preferably less than 3.5, and especially less than 3Ø The active ingredient is preferably pentamidine isethionate and the pH of the solution is preferably adjusted by the incorporation of hydrochloric acid. The solutions may be administered directly to the lung by nebulisation and are useful in the treatment of pneumo-cystic carinii pneumonia.

597544

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