Pharmaceutical composition for administration to mucosal...

Details Pharmaceutical composition for administration to mucosal... Pharmaceutical composition for administration to mucosal...

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 39/00 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2399695

A pharmaceutical composition for administration to mucosal surfaces, which composition comprises a biologically active agent, a first amount of said agent being encapsulated within microspheres which comprise a polymer which has a molecular weight in excess of 94kDa and a maximum diameter of 20 µm, and a second amount of said agent being in a form which has a higher bioavailability than said first amount. The composition is particularly useful for the intra-nasal administration of vaccines in a single shot vaccination.

Cette invention se rapporte à une composition pharmaceutique pour administration sur des surfaces muqueuses qui comprend un agent à activité biologique. Une première quantité dudit agent est encapsulée dans des microsphères qui contiennent un polymère possédant un poids moléculaire de plus de 94 kDa et un diamètre maximum de 20 µm, et une deuxième quantité dudit agent se présente sous une forme qui possède une biodisponibilité plus élevée que ladite première quantité. Cette composition est particulièrement utile pour l'administration intra-nasale de vaccins administrés sans rappel.

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