Pharmaceutical composition for combination therapy of...

A - Human Necessities – 61 – K

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A61K 31/445 (2006.01) A61K 31/165 (2006.01) A61K 31/495 (2006.01) A61K 38/04 (2006.01)

Patent

CA 1278515

ABSTRACT This invention relates to a method of treating sex steroid dependent cancers in a warm-blooded animal which comprises administering a pharmaceutically effective amount of an antiandrogen and/or an antiestrogen and/or at least one inhibitor of sex steroid biosynthesis to the animal whose hormone output of the testes or ovaries, respectively, is blocked, with the proviso that the method of treating prostate cancer comprises administering pharmaceutically effective amounts of an antiandrogen and at least one inhibitor of sex steroid biosynthesis and with the further proviso that, if antiestrogen is used in treating breast cancer it is used in association with an antiandrogen and/or at least one hinhibitor of sex steroid biosynthesis. The invention further relates to kits containing pharmaceutical compositions containing the active ingredients to be used in the novel combination therapy.

488049

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